Unraveling the correlation between Cd-induced metabolic toxicity and diabetes
Diabetes has become the first metabolic disease threatening human health. Meanwhile, the association between exposure to harmful environmental factors and the occurrence of diabetes has always been a hot topic in public health and environmental medicine.
A recent study conducted by Dr. Zhou Zhou’s laboratory at the Department of Environmental Medicine, Zhejiang University School of Medicine elucidated the metabolomic signature perturbed by Cd in pancreatic beta cells and human urine. The original article was published online in International environment on February 14, 2022.
Cadmium (Cd), as an extremely toxic heavy metal, is widely present in the environment. Cd pollution from industrial and agricultural activities is a global threat to public environmental health. The general population is exposed to Cd through foods such as rice, wheat and potatoes from polluted agricultural soils. Smoking and seafood consumption further increase Cd exposure. Epidemiological studies have indicated that urinary Cd content is clearly associated with impaired fasting blood glucose. However, there is still little information on the metabolic toxicity of Cd exposure in pancreatic β cells. The metabolic events underlying Cd exposure at the metabolome level in pancreatic β-cells and in humans remain largely unknown.
In this study, researchers first delineated the metabolomic signatures of Cd exposure in insulin-secreting MIN6 cells and in the urine of exposed workers using untargeted metabolomics. Next, they verified that these metabolic changes are related to Cd toxicity and that disrupted metabolites and pathways correlate with the pathogenesis of diabetes.
“The results of this study greatly expand our understanding of the metabolic toxicity of Cd exposure in pancreatic β-cells at the metabolome level and offer new clues to link Cd exposure to the development of diabetes mellitus,” as l said Dr. Frederic Coulon, editor-in-chief of International environment. Furthermore, the results of this study support the idea that Cd-induced metabolic toxicity could be monitored by examining disrupted urinary metabolites in humans and underscore the importance of reducing Cd exposure via drinking water. at the population level.
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Huihui Hong et al, the cadmium-disrupted metabolomic signature in pancreatic beta cells correlates with the disrupted metabolite profile in human urine, International environment (2022). DOI: 10.1016/j.envint.2022.107139
Provided by Zhejiang University
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